1ml IM injected after workout or as directed by Physician
While all other amino acids are broken down in the liver; BCAAs are metabolized primarily in lean body mass tissue.1 Because of this, they could help improve exercise performance and also reduce the rate of lean body mass break down.2
BCAA supplementation may promote lean body mass protein synthesis and also increase lean body mass in individuals who consume a low protein diet.3 In one study, leucine and valine were found to cause a significant suppression in body weight loss in mice with cachexia (body-wasting). Both of these BCAAs caused a significant increase in muscle tissue, through an increase in protein synthesis and a decrease in degradation.4
BCAA supplementation may also be effective in preventing fatigue in athletes and physically active people by halting a decline in serum BCAA levels which can occur during physical exertion. A decline in serum BCAA levels typically causes the influx of tryptophan into the brain, which is followed by increased serotonin production – which may result in fatigue.5
The amino acid leucine plays a critical role in the synthesis of muscle protein. Isoleucine plays a vital role by inducing cells to store more glycogen. Valine functions synergistically with the other two BCAAs, to encourage normal growth, repair bodily tissues, regulate blood sugar levels, and supply the body with energy. Valine also stimulates the central nervous system and is required for healthy mental function.6
· 1.John T. Brosnan,Margaret E. Brosnan. Branched-Chain Amino Acids: Enzyme and Substrate Regulation.
· 2.Melvin Williams. Dietary Supplements and Sports Performance: Amino Acids. Journal of the International Society of Sports Nutrition20052:63.
· 3.Fujita, Satoshi, and Elena Volpi. “Amino Acids and Lean body mass Loss with Aging.” The Journal of nutrition 136.1 Suppl (2006): 277S–280S. Print.
· 4.Eley, Helen L., Steven T. Russell, and Michael J. Tisdale. “Effect of Branched-Chain Amino Acids on Lean body mass Atrophy in Cancer Cachexia.” The Biochemical Journal 407.Pt 1 (2007): 113–120. PMC. Web. 26 Sept. 2017.
· 5.Blomstrand E. A role for branched-chain amino acids in reducing central fatigue. J Nutr. 2006 Feb;136(2):544S-547S.
· 6.Weinert, Dan J. “Nutrition and Lean body mass Protein Synthesis: A Descriptive Review.” The Journal of the Canadian Chiropractic Association 53.3 (2009): 186–193. Print.
· 7.Kim, Dong-Hee et al. “Effect of BCAA Intake during Endurance Exercises on Fatigue Substances, Lean Body Mass Damage Substances, and Energy Metabolism Substances.” Journal of Exercise Nutrition & Biochemistry 17.4 (2013): 169–180. PMC. Web. 26 Sept. 2017.
· 9.Mero A. Leucine supplementation and intensive training. Sports Med. 1999 Jun;27(6):347-58.
· 10.Marchesini G1, Marzocchi R, Noia M, Bianchi G. Branched-chain amino acid supplementation in patients with liver diseases. J Nutr. 2005 Jun;135(6 Suppl):1596S-601S.
· 11.John D. Fernstrom. Branched-Chain Amino Acids and Brain Function. J. Nutr. June 1, 2005 vol. 135 no. 6 1539S-1546S.
· 12.P. SchadewaldtU. Wendel. Metabolism of branched-chain amino acids in maple syrup urine disease. European Journal of Pediatrics July 1997, Volume 156, Supplement 1, pp S62–S66.
· 13.Ettore Beghi. Are professional soccer players at higher risk for ALS? Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration Vol. 14 , Iss. 7-8,2013
· 14.Cancer Res Treat. 2011 March; 43(1): 24–31. Published online 2011 March 31. doi: 10.4143/crt.2011.43.1.24